My observation is that there are many believers and even many Christian leaders who do not fulfill their God given destiny (Ephesians 2:10). This is not because they don't sense it's presence. They feel the call but for various reasons they don't respond.
One: We don't have the faith
This was the case with the ten spies who went into the promised land for Moses and then declared that the people were too strong to conquer and caused the people to roam for forty years in the desert because of their lack of faith in God. When God calls us, it requires faith to respond.
Two: We don't have the courage
Responding to God's call requires courage. We must take the first step: He will not do it for us. This was Abraham when he chose to follow God into an unknown destiny when God called him.
Three: We don't want to take the risk
Following His call can be risky. We don't know the outcome - we only have the call. This was Nehemiah who risked it all to respond to the prompting God had given him regarding Jerusalem. He was willing to risk his life and reputation for that assignment.
Four: We fear failure
This is a natural fear and it is why the command to "fear not" is the most repeated command in all of Scripture. We have much to fear but we have a God who is larger than any circumstance we could face.
Five: We don't believe God can really use us
This is Moses when he was eighty and God was calling him to lead the people out of Egypt. Here is the irony. When Moses was forty he thought he was something and God could not use him. When Moses was eighty he thought he was nothing and God could then use him.
Six: We don't believe we are qualified
Again, consider Moses who had all kinds of excuses for why he was not qualified for his assignment. Let's face it. None of us really are. That is why we need the empowerment of the Holy Spirit and the presence of Christ on a moment by moment basis. God makes us qualified!
Seven: We don't understand the role of the Holy Spirit
Romans 7: There is nothing that can separate us from the love or presence of God. We are indwelt by God. Jesus said we would do even greater things than He did when the Holy Spirit came. Every Christ follower has Jesus living in them through the Holy Spirit!
Eight: We don't understand our part in God's meta story
Life is not a random series of events. Every one of us who knows Christ steps into His story with a divine reason to be there (Ephesians 2:10). We don't know how the threads of God's tapestry connects but one day we will. Today we see the messy back side but in heaven we will see the beautiful front side.
Nine: We are caught by the expectations of others
When my father told people he was going to Hong Kong as a missionary many years ago, some prominent individuals told him that he was throwing his life away. How often others have a plan for our lives when God does as well. Who we choose to listen to makes all the difference in the world.
Ten: We are too comfortable
What if Abraham had said to God, "Look, I Googled the place you are sending me and it doesn't look too promising?" I think that is often the case. We weight the odds and think, "Hey, I am comfortable, why rock the boat."
Why follow God when He calls? It is the most exhilarating and amazing experience we could have. And what gives us the confidence to step into our destiny? It is as David said to Saul before he went up against Goliath. I have met the bear and the lion and God gave them into my hand. He based his faith on what God had done in the past and we can as well.